Auristatins

TBD-Biodiscovery has a good experience with producing antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin. The family of auristatins are synthetic analogues of the antineoplastic natural product Dolastatin 10.

Auristatins are 100-1000 times more potent than Doxorubicin.

Monomethyl auristatin E free base (MMAE)Monomethyl auristatin E free base (MMAE)

CAS: 474645-27-7
C39H67N5O7
Purity: 98,8% (HPLC)
Quantities: Available in gram quantities (>10 g)
Availability: In stock
TBD MMAE data sheet.pdf

 

Monomethyl auristatin F free base (MMAF)Monomethyl auristatin F free base (MMAF)

CAS: 745017-94-1
C39H65N5O8
Purity: 99.7% (HPLC)
Quantities: Available in gram quantities (>10 g)
Availability: In stock
TBD MMAF data sheet.pdf

 

Monomethyl auristatin F methyl ester free base (MMAF-OMe)Monomethyl auristatin F methyl ester free base (MMAF-OMe)

CAS: 863971-12-4
C40H67N5O8
Purity: 95 – 98% (HPLC)
Quantities: Available in gram quantities (>10 g)
Availability: 2-4 weeks

 

Auristatin F free base (DMAF)Auristatin F free base (DMAF)

CAS: 163768-50-1
C40H67N5O8
Purity: 95 – 98% (HPLC)
Quantities: Available in gram quantities (>10 g)
Availability: 2 – 4 weeks
TBD DMAF data sheet.pdf

 

Monomethyl auristatin D free base (MMAD) – coming soon!Monomethyl auristatin D free base (MMAD) – coming soon!

CAS: 203849-91-6
C41H66N6O6S
Purity: 95 – 98% (HPLC)
Quantities: Available in gram quantities (>10 g)

 

Conjugates of auristatins

  • Conjugates with cleavable and non-cleavable linkers  g. Val-Ala-PABC-MMAE etc
  • Different spacers can be included
  • Purity of 95-99% (HPLC)
  • We offer linker-to-toxin (auristatin) conjugation as a service.