PAYLOAD – LINKER CUSTOM CONJUGATION

PROCESS

  • Both well-known payloads and novel payloads can be used
  • Both well-known linkers and novel linkers can be used
  • Upscale to 1-10 g if necessary
  • Development of purification methods (precipitation, flash or prep HPLC)

ANALYSES

  • Structural analysis (2D NMR and HRMS)
  • Plasma stability
  • Enzymatic cleavage study (e.g. with mouse/human cathepsin)